/* */ PELVIPHARM - Myocardial ischemia / Reperfusion in rats
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Myocardial ischemia / Reperfusion in rats

Objectives

Myocardial ischemia – reperfusion in rats provides a useful method to study myocardial protection using pharmacological agents. (see myocardial infarction)

Summarized methodology:

  • Myocardial ischemia is induced by the occlusion of the left anterior descending (LAD) coronary artery in anesthetized animals.
  • At the end of the ischemic period (if needed), reperfusion is performed by releasing the coronary suture under anesthesia.
  • In the case of prolonged protocols, the rats can be allowed to recover from anesthesia after surgery.

Experimental period can vary from hours to several days-weeks according to the client’s needs
(figure 1).

Figure 1: Summary of possible experimental designs.
Figure 1: Summary of possible experimental designs.

Endpoints

Related Pelvipharm bibliography
Non disclosable information for confidentiality reasons

Links to applicable Targeted disorders / Pathophysiological models

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