Histomorphometry
Objectives
In addition to organ weighing, and morphological examination, several histomorphometric measurements can be performed to quantitatively evaluate the remodeling of a tissue.
Summarized methodology
Following tissue staining, images are captured using a light microscope (Eclipse E800, Nikon, France – Figure 1) connected to a video camera (Digital camera DXM1200, Nikon, France), and histomorphometric measurements are performed by computerized image analysis system (NIS-elements software®).
 |
|
Figure 1: Overview of the microscope set-up. |
Endpoints
Different parameters can be evaluated according to the type of tissue to be examined
 |
Related Pelvipharm bibliography
Behr-Roussel, D. et al.
J Sex Med (2006) : 3(4):596-603
Behr-Roussel, D. et al.
Atherosclerosis (2002) : 162:355-362
J Sex Med (2006) : 3(4):596-603
Behr-Roussel, D. et al.
Atherosclerosis (2002) : 162:355-362
Links to applicable Targeted disorders / Pathophysiological models
- Atherosclerosis
- BPH (Benign Prostatic Hyperplasia)
- Diabetes
- ED (Erectile Dysfunction)
- Ejaculatory disorders (premature or delayed ejaculation / anejaculation)
- FSD (Female Sexual Dysfunction)
- Hypertension
- IC (Interstitial Cystitis) / Painful bladder syndrome
- Metabolic Syndrome and Obesity
- Myocardial Infarction
- NDO (Neurogenic Detrusor Overactivity)
- OAB (Overactive Bladder)
- SCI (Spinal Cord Injury)
Download this page in PDF