In addition to organ weighing, and morphological examination, several histomorphometric measurements can be performed to quantitatively evaluate the remodeling of a tissue.
Following tissue staining, images are captured using a light microscope (Eclipse E800, Nikon, France – Figure 1) connected to a video camera (Digital camera DXM1200, Nikon, France), and histomorphometric measurements are performed by computerized image analysis system (NIS-elements software®).
Figure 1: Overview of the microscope set-up.
Different parameters can be evaluated according to the type of tissue to be examined
J Sex Med (2006) : 3(4):596-603
Behr-Roussel, D. et al.
Atherosclerosis (2002) : 162:355-362
Links to applicable Targeted disorders / Pathophysiological models