Bladder outlet obstruction (BOO)

Model’s advantages

shows many of the morphological and functional changes as those seen in patients with severe bladder outlet obstruction
allows changes to develop overtime as the animal grows and becomes progressively more obstructed
useful to investigate the effect of drugs known to act on both bladder smooth muscle and afferent responses

SPECIES

rat, rabbit

Pathophysiological features

Morphological changes: smooth muscle hyperplasia and hypertrophy
Functional changes: increased bladder capacity, residual volume, and micturition pressure in addition to the occurrence of detrusor overactivity characterized by non-voiding contractions

Figure 1: Representative cystometrograms in conscious 6 weeks BOO and sham rats. Arrows indicate the voiding contractions. Detrusor overactivity occurred in the BOO rat but were not detected in sham rats. (Pelvipharm, internal data).

Summarized methodology

A calibrated gold jeweler’s jump ring, is twisted open and passed around the proximal urethra. It is freely mobile around the urethra; thus, as the animal grows, progressive bladder outlet obstruction develops. The pathology develops 4-6 weeks after BOO. Urodynamic evaluation can then be performed (cf. Links to applicable experimental skills).

NB: Pelvipham will gladly study the feasibility to fit this experimental model in order to meet its client’s needs.

Related Pelvipharm bibliography

Oger, S. et al.
Eur Urol Suppl (2007) : 6(2):102 (EAU, 2007)

Oger, S. et al.
J Urol (2007) : 177(4) (AUA, 2007)

Julia-Guilloteau, V. et al.
Eur Urol (2006) : 5(2):78 (EAU, 2006)

Links to applicable Experimental skills

Download this page in PDF