Testosterone-supplemented SHR as a model of BPH / male LUTS
The testosterone-supplemented SHR combines erectile dysfunction, prostate enlargement and urodynamic impairment characteristic of LUTS and allows thus the assessment of erectile function in parallel to bladder function and prostate size.
This model helps to assess the sexual side-effect profile of new therapeutic strategies for BPH while evaluating their efficacy on LUTS and prostate enlargement.
- Dramatic impairment of erectile responses to electrical stimulation of the cavernous nerve after 3 weeks of testosterone supplementation in anesthetized SHR (figure 1).
- Exhibits abnormal bladder function: decreased ICI, voided volume and bladder capacity, and increased urinary frequency and amplitude of non voiding contractions characteristic of detrusor overactivity.
The testosterone-supplemented SHR exhibits several common characteristics with the human pathology:
- Prostatic enlargement (figure 3)
J Urol (2011) : 185, 4, Suppl 1, p.e631
Oudot A., et al.
J Sex Med (2010) : 7(s6)
Links to applicable Experimental skills