/* */ PELVIPHARM - In vitro organ baths functional experiments with animal tissues
Receive our news


In vitro organ baths functional experiments with animal tissues

Animal tissues

  • In vitro functional investigation of animal tissue function in normal and pathophysiological conditions.
  • Unrestricted amount of tissue.
  • Evaluation of the ability of drugs at modulating different smooth muscle tone can be performed on contractile or relaxant response elicited by pharmacological agents or by electrical field stimulation (EFS).
  • Evaluation of mRNA by RT-PCR or protein expression, by immunohistochemistry (IHC) or western-blot (WB), in parallel of organ bath studies.

 CRC = concentration-response curve

 CRC = concentration-response curve

NB: Pelvipham will gladly study the feasibility of performing additional in vitro assays on other species to meet its client’s needs.


  • Evaluation of the capacity of a drug to inhibit detrusor smooth muscle contractile activity.
  • Determination of potency (EC50) and efficiency (Emax) of a drug.
  • Determination of the affinity (pA2) of a drug for a human bladder receptor.
Related Pelvipharm bibliography
Oudot A. et al.
Physiol Res (2009) : 58(4):499-509

Behr-Roussel D. et al.
Eur Urol (2008) : 53(6):1272-1281

Oger S. et al.
J Urol (2007) : 177(4): # 257 (AUA, 2007)

Oger S. et al.
Eur Urol (2007) : 6(2):272 (EAU, 2007)

Behr-Roussel D. et al.
Eur. Urol. (2005) : 47(1):87-91

Behr-Roussel D. et al.
Am. J. Physiol. (2005) : 288(1):R276-283

Behr-Roussel D., et al.
Am. J. Physiol. (2003) : 284(3):R682-688
TEL +331 704 293 39
FAX + 331 704 295 10