Myocardial ischemia / Reperfusion in rats
Myocardial ischemia – reperfusion in rats provides a useful method to study myocardial protection using pharmacological agents. (see myocardial infarction)
- Myocardial ischemia is induced by the occlusion of the left anterior descending (LAD) coronary artery in anesthetized animals.
- At the end of the ischemic period (if needed), reperfusion is performed by releasing the coronary suture under anesthesia.
- In the case of prolonged protocols, the rats can be allowed to recover from anesthesia after surgery.
Experimental period can vary from hours to several days-weeks according to the client’s needs
|Figure 1: Summary of possible experimental designs.|
Links to applicable Targeted disorders / Pathophysiological models