Testosterone-induced rat model of BPH
The main advantage of the testosterone-induced rat model of BPH is that it presents an enlargement of the prostate sharing common characteristics with human BPH and thus allowing studies on the causative mechanism of BPH symptoms by specifically targeting the prostatic growth and its final consequences.
Prostate features :
The testosterone-induced rat model of BPH exhibits several common characteristics with the human pathology :
- Prostatic enlargement
- Both stromal and epithelial compartments proliferation (figure 1).
- Abnormal bladder function similar to that of patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: increase in bladder capacity, in maximal amplitude of bladder contractions and in residual volume, occurrence of non voiding contractions
- Bladder hypertrophy
|Figure 2: Representative cystometrograms in conscious testosterone or vehicle-treated rats. (Pelvipharm, internal data).
- Increase in urethral pressure
- Increase in urethral phenylephrine-responsiveness in vivo
The hormonal-induced prostate hypertrophy in rats is induced by the daily subcutaneous delivery of testosterone (figure 3).
|Figure 3: Evaluation of prostate enlargement induced by daily s.c. testosterone injections (3mg/kg during 3 weeks) (Pelvipharm, internal data)|
Eur Urol (2006) : 5(2):119 (EAU, 2006)
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