Administration routes / Treatment

Objectives

The evaluation of the effects of a compound requires its administration. This can be performed using various routes and frequencies. Moreover, some pathophysiological models are pharmacologically-induced and also require administration of substance(s).

Summarized methodology

Various administrations routes can be proposed as described in figure 1.

Figure 1: Administration routes.

Several administration modalities are available in conscious (restrained and unrestrained) or anesthetized animals:
- Acute: single administration
- Chronic: repeated or continuous administration (direct administration, via catheterisation, osmotic pump, in chow or drinking water)

Note: Pelvipharm staff is highly trained to every route of administration

Endpoints

Evaluation of the effects of a compound and its vehicle on a variety of experimental pathophysiological models
Pharmacological induction of a pathophysiological model

NB: Pelvipharm will gladly study the feasibility of additional administration routes and modalities to meet its client’s needs.

Related Pelvipharm bibliography

Oudot, A. et al.
J Sex Med (2010) : 7(1)p1:79-88

Behr-Roussel, D. et al.
Am J Hypertens (2008): 21(11):1258-1263

Clément, P. et al.
Br J Pharmacol (2008): 154(5):1150-1159

Behr-Roussel, D. et al.
Eur Urol (2008): 53(6):1272-1281

Clément, P. et al.
Neuroscience (2007): 145(2):605-610

Rossler, A.S. et al.
J Sex Med (2006) : 3:432–441

Giuliano, F. et al.
Neuroscience (2006): 138(1):293-301

Behr-Roussel, D. et al.
Eur Urol (2005) :47(1):87-91

Giuliano, F. et al.
BJU Int (2004) : 93(4):605-608

Sironi, G. et al.
J Pharmacol Exp Ther (2000): 292(3) :974-981

Links to applicable Targeted disorders / Pathophysiological models

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