/* */ PELVIPHARM - Measurement of tail skin temperature: a model of menopausal hot flushes / flashes
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Measurement of tail skin temperature: a model of menopausal hot flushes / flashes

Objectives:


  • To evaluate skin vasomotion, a primary heat loss mechanism that can be monitored by changes in tail skin temperature
  • To monitor changes in rat tail skin temperature of ovariectomized female rats used as a model of hot flushes / flashes
  • Relevant model to evaluate the effects of drugs developed to treat menopausal vasomotor symptoms including hot flushes / flashes

Summarized methodology:Endpoints:


Adult female rat are ovariectomized bilaterally through a dorsal incision under general anesthesia. At least 2 weeks of post-surgical period to induce artificial menopause, the tail skin temperature is measured in a freely moving female rat using a thermocouple with a probe implanted in the rat tail (Pan et al., 2001; Williams et al., 2010; Yoneda et al., 2011).


Illustration_of_the_thermocouple_used_for_rat_tail_skin_temperature_measurement.jpg


Figure 1: Illustration of the thermocouple used for rat tail skin temperature measurement.


  • Basal tail skin temperature (after ovariectomy but before treatment administration)
  • Change in tail skin temperature (after treatment administration)


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